Time-course of mdx and wild type mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rolf Turk
PROVIDER: E-GEOD-1574 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling.
Turk R R Sterrenburg E E de Meijer E J EJ van Ommen G-J B GJ den Dunnen J T JT 't Hoen P A C PA
BMC genomics 20050713
<h4>Background</h4>Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age.<h4>Results</h4>Out of 7776 genes, 1735 were differentially expressed between md ...[more]
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