Mouse Models for Muscular Dystrophy
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Peter 't Hoen
PROVIDER: E-GEOD-2112 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Common pathological mechanisms in mouse models for muscular dystrophies.
Turk R R Sterrenburg E E van der Wees C G C CG de Meijer E J EJ de Menezes R X RX Groh S S Campbell K P KP Noguchi S S van Ommen G J B GJ den Dunnen J T JT 't Hoen P A C PA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051123 1
Duchenne/Becker and limb-girdle muscular dystrophies share clinical symptoms like muscle weakness and wasting but differ in clinical presentation and severity. To get a closer view on the differentiating molecular events responsible for the muscular dystrophies, we have carried out a comparative gene expression profiling of hindlimb muscles of the following mouse models: dystrophin-deficient (mdx, mdx(3cv)), sarcoglycan-deficient (Sgca null, Sgcb null, Sgcg null, Sgcd null), dysferlin-deficient ...[more]
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