Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mohammad Qadura
PROVIDER: E-GEOD-15809 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Qadura Mohammad M Waters Braden B Burnett Erin E Chegeni Rouzbeh R Bradshaw Scott S Hough Christine C Othman Maha M Lillicrap David D
Blood 20090501 4
The use of plasma-derived factor VIII (pdFVIII) concentrates in hemophilia A has been reported to result in reduced anti-FVIII antibody formation. In this study, we have investigated whether the cytokine microenvironment induced by pdFVIII has an influence on reducing anti-FVIII antibody titers in hemophilic mice. Microarray and confirmatory quantitative reverse transcription polymerase chain reaction (RT-PCR) experiments show that pdFVIII infusion causes a different transcriptional profile in d ...[more]