Unknown,Transcriptomics,Genomics,Proteomics

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Recombinant and plasma-derived Factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A


ABSTRACT: To investigate the gene expression in dendritic cells after treating hemiphilic mice with HBSS, plasma derived or recombinant factor VIII Gene expression in dendritic cells were measured 24 hours post treatment Hemophilic mice with treated with either (HBSS, rFVIII or pdFVIII) 24 hours post treatment the spleens were isolated and CD11+ DCs were purified. The gene expression in the DCs were then investigated by microarray studies.

ORGANISM(S): Mus musculus

SUBMITTER: Mohammad Qadura 

PROVIDER: E-GEOD-15809 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice.

Qadura Mohammad M   Waters Braden B   Burnett Erin E   Chegeni Rouzbeh R   Bradshaw Scott S   Hough Christine C   Othman Maha M   Lillicrap David D  

Blood 20090501 4


The use of plasma-derived factor VIII (pdFVIII) concentrates in hemophilia A has been reported to result in reduced anti-FVIII antibody formation. In this study, we have investigated whether the cytokine microenvironment induced by pdFVIII has an influence on reducing anti-FVIII antibody titers in hemophilic mice. Microarray and confirmatory quantitative reverse transcription polymerase chain reaction (RT-PCR) experiments show that pdFVIII infusion causes a different transcriptional profile in d  ...[more]

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