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Expression profiling of dme-miR-310 cluster (miR-310, miR-311, miR-312, miR-313) knockout


ABSTRACT: Expression profiling of the dme-miR-310 cluster knockout line in D.melanogaster. The knockout line was generated in an imprecise P-element excision screen using a stock P{EP}2587 containing a P-element insertion directly upstream of the miR-310 cluster. The precise excision line of P{EP}2587 was used as the control. The expression of miR-310 cluster knockout line (imprecise deletion of P{EP}2587 insertion) were compared with the control (precise deletion of P{EP}2587 insertion) using Drosophila Tiling 1.0 F array. Each stock has three biological repeats. A processed data matrix reporting values (log2 intensity after quantile normalization) for all of the Samples is linked below as a supplementary file.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: TIAN TANG 

PROVIDER: E-GEOD-15851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Adverse interactions between micro-RNAs and target genes from different species.

Tang Tian T   Kumar Supriya S   Shen Yang Y   Lu Jian J   Wu Mao-Lien ML   Shi Suhua S   Li Wen-Hsiung WH   Li Wen-Hsiung WH   Wu Chung-I CI  

Proceedings of the National Academy of Sciences of the United States of America 20100706 29


It is commonly assumed but not proven that microRNAs (miRNAs) and their targets coevolve. Under this assumption, miRNAs and targets from different species may interact adversely, resulting in reduced fitness. However, the strength of the adverse interactions may not be detectable because even outright deletions of miRNAs often manifest only subtle fitness effects. We tested and measured the strength of heterospecific interactions by carrying out transgenic experiments across Drosophila species b  ...[more]

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