Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Janis Weis
PROVIDER: E-GEOD-16195 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ma Ying Y Miller Jennifer C JC Crandall Hillary H Larsen Eric T ET Dunn Diane M DM Weiss Robert B RB Subramanian Meenakumari M Weis John H JH Zachary James F JF Teuscher Cory C Weis Janis J JJ
Infection and immunity 20090601 8
The observation that Borrelia burgdorferi-induced arthritis is severe in C3H mice and milder in C57BL/6 (B6) mice has allowed a forward genetics approach for the identification of genetic elements that regulate the arthritis response. Quantitative trait loci (QTL) on five chromosomes (Chr) were identified previously in segregating crosses between C3H and B6 mice and collectively designated B. burgdorferi arthritis-associated (Bbaa) QTL. Reciprocal interval-specific congenic lines (ISCL) that enc ...[more]