Age-associated alteration of gene expression patterns in mouse oocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Toshio Hamatani
PROVIDER: E-GEOD-1646 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Age-associated alteration of gene expression patterns in mouse oocytes.
Hamatani Toshio T Falco Geppino G Carter Mark G MG Akutsu Hidenori H Stagg Carole A CA Sharov Alexei A AA Dudekula Dawood B DB VanBuren Vincent V Ko Minoru S H MS
Human molecular genetics 20040818 19
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in oocytes, about 5% (530) showed statistically significant expression changes, excludi ...[more]
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