Normal human fibroblast cell line bystander effects by Carbon ion irradiation

ABSTRACT: We have recently investigated the response of irradiated and bystander fibroblasts to heavy ions in confluent cultures exposed randomly to broadbeam and selectively to precision microbeam that target a predefined fraction of cells with counted number of particle(s), respectively, and found the difference in the time course of apoptosis induction and p53 phosphorylation between irradiated and bystander cells [Hamada MR2008]. In the present investigation, to further scrutinize the underpinnings of their temporally distinct responses, we set out to examine the gene expression changes in irradiated and bystander fibroblasts at a genome-wide level with the microarray analysis under the same experimental condition. We demonstrate that the gene expression profiles of bystander cells are substanti

ORGANISM(S): Homo sapiens

SUBMITTER: Kaori Imadome 

PROVIDER: E-GEOD-8993 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress