The absence of a Ca(2+) signal during mouse egg activation can affect development and gene expression patterns
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Guillaume Halet
PROVIDER: E-GEOD-5077 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The absence of a Ca(2+) signal during mouse egg activation can affect parthenogenetic preimplantation development, gene expression patterns, and blastocyst quality.
Rogers N T NT Halet G G Piao Y Y Carroll J J Ko M S H MS Swann K K
Reproduction (Cambridge, England) 20060701 1
A series of Ca(2+) oscillations during mammalian fertilization is necessary and sufficient to stimulate meiotic resumption and pronuclear formation. It is not known how effectively development continues in the absence of the initial Ca(2+) signal. We have triggered parthenogenetic egg activation with cycloheximide that causes no Ca(2+) increase, with ethanol that causes a single large Ca(2+) increase, or with Sr(2+) that causes Ca(2+) oscillations. Eggs were co-treated with cytochalasin D to mak ...[more]
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