Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Interleukin-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice

ABSTRACT: The gene expression difference between CBA/J and DBA/2 mice after the injection of CAWS (Candida albicans water-soluble fraction) was compared using an oligo-DNA microarray. CAWS was injected into CBA/J and DBA/2 mice. 21 days after the injection, RNA was extracted from the splenocytes and measured using the mouse oligo-DNA 10K micoarray.

ORGANISM(S): Mus musculus

SUBMITTER: Naoki Osada

PROVIDER: E-GEOD-16529 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA/N mice.

Miura Noriko N NN Komai Motohiko M Adachi Yoshiyuki Y Osada Naoki N Kameoka Yosuke Y Suzuki Kazuo K Ohno Naohito N

Journal of immunology (Baltimore, Md. : 1950) 20090812 5

Candida albicans water-soluble fraction (CAWS), a mannoprotein-beta-glucan complex obtained from the culture supernatant of C. albicans NBRC1385, exhibits vasculitis-inducing activity (CAWS-vasculitis) in mice. The sensitivity to CAWS-vasculitis varies greatly among mouse strains. This study examined the factors contributing to or inhibiting CAWS-vasculitis using CAWS-vasculitis-resistant CBA/J mice and Bruton's tyrosine kinase-deficient CBA/N mice, which is a CAWS-vasculitis-sensitive strain th ...[more]

PMID: 19675170

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Dataset Information

Interleukin-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice

Publications

IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA/N mice.

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