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Gene expression in human subcutaneous adipose tissue after CLA intervention

ABSTRACT: Iisomer-specific effects of conjugated linoleic (CLA) supplementation on gene expression with particular consideration of the PPAR 2 Pro12Ala SNP in human adipose tissue. Effect of CLA supplementation on genome wide gene expression in adipose tissue biopsies from 5 PPARg2 Ala12Ala and 5 PPARg2 Pro12Pro men were investigated. Subjects underwent four intervention periods (4wk) in a randomized double blind cross-over design receiving f either cis-9, trans-11 CLA, trans-10,cis-12 CLA, 1:1 mixture of both isomers or a reference oil preparation. After each intervention biopsies were taken and whole genome expression microarrays were applied.

ORGANISM(S): Homo sapiens

SUBMITTER: Julia Herrmann

PROVIDER: E-GEOD-16615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study.

Herrmann J J Rubin D D Häsler R R Helwig U U Pfeuffer M M Auinger A A Laue C C Winkler P P Schreiber S S Bell D D Schrezenmeir J J

Lipids in health and disease 20090818

<h4>Background</h4>Peroxisome proliferator-activated receptor (PPAR)gamma is a key regulator in adipose tissue. The rare variant Pro12Ala of PPARgamma2 is associated with a decreased risk of insulin resistance. Being dietary PPARgamma ligands, conjugated linoleic acids (CLAs) received considerable attention because of their effects on body composition, cancer, atherosclerosis, diabetes, obesity and inflammation, although some effects were only demonstrated in animal trials and the results in hum ...[more]

PMID: 19689798

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