Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Beth Yun
PROVIDER: E-GEOD-16741 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100601 22
MicroRNAs, by modulating gene expression, have been implicated as regulators of various cellular and physiological processes, including differentiation, proliferation, and cancer. Here, we study the role of microRNAs in Schwann cell (SC) differentiation by conditional removal of the microRNA processing enzyme Dicer1. We reveal that both male and female mice lacking Dicer1 in SC (Dicer1 conditional knock-outs) display a severe neurological phenotype resembling congenital hypomyelination. Ultrastr ...[more]