Transcription profiling of human chondrosarcoma cells resistant to ET-743 and PM00104
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ABSTRACT: ET-743 (trabectedin, Yondelis®) and PM00104 (Zalypsis®) are marine derived compounds that have antitumor activity. ET-743 and PM00104 exposure over sustained periods of treatment will result in the development of drug resistance, but the mechanisms which lead to resistance are not yet understood. Human chondrosarcoma cell lines resistant to ET-743 (CS-1/ER) or PM00104 (CS-1/PR) were established in this study. The CS-1/ER and CS-1/PR exhibited cross resistance to cisplatin and methotrexate but not to doxorubicin. Human Affymetrix Gene Chip arrays were used to examine relative gene expression in these cell lines. Experiment Overall Design: Three samples CS-1/ER, CS-1/PR and CS-1 were compared.
ORGANISM(S): Homo sapiens
SUBMITTER: Zhenfeng Duan
PROVIDER: E-GEOD-16748 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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