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SiRNA of human HeLa cells with RENT1 knockdown

ABSTRACT: HeLa cells were treated with siRNA directed against Luciferase or RENT1 in duplicate (as described in Mendell et al., Science, 2002; PubMed ID:12228722). Transcripts that are differentially expressed between the two experimental conditions are putatively regulated by RENT1.

ORGANISM(S): Homo sapiens

SUBMITTER: Joshua Mendell 

PROVIDER: E-GEOD-1703 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.

Mendell Joshua T JT   Sharifi Neda A NA   Meyers Jennifer L JL   Martinez-Murillo Francisco F   Dietz Harry C HC  

Nature genetics 20040926 10

Premature termination codons induce rapid transcript degradation in eukaryotic cells through nonsense-mediated mRNA decay (NMD). This pathway can modulate phenotypes arising from nonsense or frameshift mutations, but little is known about the physiologic role of NMD in higher eukaryotes. To address this issue, we examined expression profiles in mammalian cells depleted of Rent1 (also called hUpf1), a factor essential for NMD. Upregulated transcripts included those with upstream open reading fram  ...[more]

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