Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lieven Thorrez
PROVIDER: E-GEOD-17140 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
De Bruyne Elke E Bos Tomas J TJ Schuit Frans F Van Valckenborgh Els E Menu Eline E Thorrez Lieven L Atadja Peter P Jernberg-Wiklund Helena H Vanderkerken Karin K
Blood 20100119 12
Insulin-like growth factor-1 (IGF-1) is an important growth and survival factor in multiple myeloma (MM). Here, we demonstrate that IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in MM cells. Reduced Bim levels by RNA interference (RNAi) protected cells from drug-induced cell death. The IGF-1-mediated down-regulation of Bim was the result of (1) reduced transcription by activation of the Akt pathway and inactivation of the transcription factor FoxO3a, (2) incr ...[more]