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ConA-induced fulminant hepatitis in a mouse model

ABSTRACT: The goal of this experiment was to investigate the early mechanisms of human fulminant hepatitis through ConA-induced hepatitis model.Early diagnosis and interventions are important for patients with fulminant hepatitis and gene expression may be pivotal in the early diagnosis. Keyword :ConA-induced hepatitis model ConA was injected through the mouse caudal vein at one of 4 time points (0 hr, 1 hr, 3 hr, 6 hr). The effects of ConA treatment on hepatic gene expression at these time points were analyzed .There are 3 replicates at each timepoint then 4*3=12 samples in all.

ORGANISM(S): Mus musculus

SUBMITTER: Dong Cheng Liu 

PROVIDER: E-GEOD-17184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model.

Chen Feng F   Zhu Hai-Hong HH   Zhou Lin-Fu LF   Li Jie J   Zhao Li-Ying LY   Wu Shan-Shan SS   Wang Jing J   Liu Wei W   Chen Zhi Z  

BMC genomics 20100415

<h4>Background</h4>Due to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little is known about the gene expression changes in the early stage of this serious illness. Identification of the genes related to the very early stage of fulminant hepatitis development may provide precise clues for early diagnosis.<h4>Results</h4>Balb/C mice were used for ConA injection to induce fulminant hepat  ...[more]

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