Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ConA-induced fulminant hepatitis in a mouse model

ABSTRACT: The goal of this experiment was to investigate the early mechanisms of human fulminant hepatitis through ConA-induced hepatitis model.Early diagnosis and interventions are important for patients with fulminant hepatitis and gene expression may be pivotal in the early diagnosis. Keyword :ConA-induced hepatitis model

ORGANISM(S): Mus musculus

PROVIDER: GSE17184 | GEO | 2009/07/21

SECONDARY ACCESSION(S): PRJNA119679

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ConA-induced fulminant hepatitis in a mouse model

Project description:The goal of this experiment was to investigate the early mechanisms of human fulminant hepatitis through ConA-induced hepatitis model.Early diagnosis and interventions are important for patients with fulminant hepatitis and gene expression may be pivotal in the early diagnosis. Keyword :ConA-induced hepatitis model ConA was injected through the mouse caudal vein at one of 4 time points (0 hr, 1 hr, 3 hr, 6 hr). The effects of ConA treatment on hepatic gene expression at these time points were analyzed .There are 3 replicates at each timepoint then 4*3=12 samples in all.

2009-07-21 | E-GEOD-17184 | biostudies-arrayexpress

Mus musculus

Project description:ConA-induced fulminant hepatitis in a mouse model

| PRJNA119679 | ENA

RNA-seq of plko-scramble or shBicd2 plasmid hydrodynamic-injected mice livers under ConA-induced acute autoimmune hepatitis

Project description:To explore the effect of Bicd2 in ConA-induced acute autoimmune hepatitis, we conducted RNA transcriptome profiling of plko-scramble or shBicd2 plasmid hydrodynamic-injected mice livers in response to ConA injection.

2023-10-31 | GSE245352 | GEO

Effect of YTHDF1 on concanavalin A-induced hepatitis

Project description:To investigate the effect of YTHDF1 on concanavalin A (ConA)-induced hepatitis , we performed RNA-seq with the total RNA extracted from the moue liver. Ythdf1-/- or wild type mice were intravenously injected with ConA (8 mg/kg) or saline for 8 hours. Then, the livers were collected, homogenized, and subjected to total RNA extraction.

2023-08-08 | GSE238229 | GEO

Effect of a DP1 agonist BW245C on concanavalin A-induced hepatitis

Project description:To elucidate the effect of a prostaglandin D2 receptor DP1 agonist BW245C on concanavalin A (ConA) hepatitis, we performed DNA microarray using SurePrint G3 Mouse GE 8x60K Microarray. Mice were treated with ConA for 3 or 24 hr with vehicle or BW245C . Livers were collected, homogenized, and subjected to total RNA extraction.

2015-06-01 | GSE45413 | GEO

Distinct serum microRNA profiles in patients with active autoimmune hepatitis

Project description:Serum microRNAs are useful for the early diagnosis and management of autoimmune hepatitis

2022-04-27 | GSE140249 | GEO

Gene expression profiling in acute murine autoimmune hepatitis

Project description:The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways dependent on IFN-γ as possible targets for rational therapy, and to test potential targets directly in vivo in mice. Keywords: Comparative analysis of gene expression in livers of WT, TGFB1 & IFN knockout mice

2009-02-28 | GSE9892 | GEO

Gene expression profiling in acute murine autoimmune hepatitis

2009-02-28 | E-GEOD-9892 | biostudies-arrayexpress

Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling

Project description:Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions. Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions.

2013-11-14 | E-GEOD-44074 | biostudies-arrayexpress

Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling

2013-11-14 | GSE44074 | GEO