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TGFbeta signalling in fibroblasts.

ABSTRACT: Murine embryonic fibroblasts, wild type or Alk5 knock outs, stimulated and unstimulated with TGFbeta.

ORGANISM(S): Mus musculus

SUBMITTER: GÃ¶ran Karlsson

PROVIDER: E-GEOD-1742 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.

Karlsson Göran G Liu Yingchun Y Larsson Jonas J Goumans Marie-José MJ Lee Ju-Seog JS Thorgeirsson Snorri S SS Ringnér Markus M Karlsson Stefan S

Physiological genomics 20050315 3

Transforming growth factor-beta1 (TGF-beta) regulates cellular functions like proliferation, differentiation, and apoptosis. On the cell surface, TGF-beta binds to receptor complexes consisting of TGF-beta receptor type II (TbetaRII) and activin-like kinase receptor-5 (Alk5), and the downstream signaling is transduced by Smad and MAPK proteins. Recent data have shown that alternative receptor combinations aside from the classical pairing of TbetaRII/Alk5 can be relevant for TGF-beta signaling. W ...[more]

PMID: 15769904

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