Transcriptional profiling of the Borrelia burgdorferi bb0647 mutant
Ontology highlight
ABSTRACT:
ORGANISM(S): Borrelia burgdorferi
SUBMITTER: Zhiming Ouyang
PROVIDER: E-GEOD-17422 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
BosR (BB0647) governs virulence expression in Borrelia burgdorferi.
Ouyang Zhiming Z Kumar Manish M Kariu Toru T Haq Shayma S Goldberg Martin M Pal Utpal U Norgard Michael V MV
Molecular microbiology 20091102 6
Summary Borrelia burgdorferi (Bb), the Lyme disease spirochaete, encodes a potential ferric uptake regulator (Fur) homologue, BosR (BB0647). Thus far, a role for BosR in Bb metabolism, gene regulation or pathogenesis has not been determined, largely due to the heretofore inability to inactivate bosR in low-passage, infectious Bb isolates. Herein, we report the generation of the first bosR-deficient mutant in a virulent strain of Bb. Whereas the bosR mutant persisted normally in ticks, the mutant ...[more]
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