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Expression data from K5-IKKbeta transgenic mouse skin

ABSTRACT: IKKbeta is a subunit of the IkB kinase (IKK) complex required for NF-kB activation in response to pro-inflammatory signals. NF-kB regulates the expression of many genes involved in inflammation, immunity and apoptosis, and also controls cell proliferation and differentiation in different tissues; however, its function in skin physiopathology remains controversial. We here report the alterations caused by increased IKKbeta activity in basal cells of the skin of transgenic mice. Transgenic mice which express the IKKbeta gene under the control of the keratin K5 regulatory elements were generated. We analyzed back skins from wildtype and transgenic animals. Each individual array has RNA from three different mice of the same genotype.

ORGANISM(S): Mus musculus

SUBMITTER: Manuel Navarro

PROVIDER: E-GEOD-17511 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.

Page Angustias A Navarro Manuel M Garín Marina M Pérez Paloma P Casanova M Llanos ML Moreno Rodolfo R Jorcano José L JL Cascallana José L JL Bravo Ana A Ramírez Angel A

The Journal of investigative dermatology 20100304 6

IKKbeta is a subunit of the IkappaB kinase (IKK) complex required for NF-kappaB activation in response to pro-inflammatory signals. NF-kappaB regulates the expression of many genes involved in inflammation, immunity, and apoptosis, and also controls cell proliferation and differentiation in different tissues; however, its function in skin physiopathology remains controversial. In this study we report the alterations caused by increased IKKbeta activity in skin basal cells of transgenic mice. The ...[more]

PMID: 20200541

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Expression data from K5-IKKbeta transgenic mouse skin

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