Transcriptomics

Dataset Information

0

Expression data from small intestine of NFKBIA-KO mice versus wild type


ABSTRACT: The IkB-Kinase (IKK)-NF-kB signaling pathway plays a multifaceted role in Inflammatory Bowel Disease: One the one hand it protects cells from apoptosis, but on the other, it activates transcription of numerous inflammatory cytokines and chemokines. To examine the role of constitutive NF-kB signaling in intestinal epithelium cells (IEC), we generated a mouse model with a tissue-specific knockout of the direct inhibitor of NF-kB, IkBα. We demonstrate that in IκBαIEC-KO mice, constitutive activation of NF-kB in epithelium leads to abnormal intestinal development, enlarged peyer’s patches, loss of Paneth cells, and spontaneous inflammation. We performed expression analysis of IκBαIEC-KO mice compared to wildtype by using the Affymetrix array Clariom S mouse.

ORGANISM(S): Mus musculus

PROVIDER: GSE139251 | GEO | 2020/03/22

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-05-09 | PXD037534 | JPOST Repository
2009-05-01 | GSE13599 | GEO
2010-03-22 | GSE17511 | GEO
2015-07-20 | GSE47078 | GEO
2015-07-20 | GSE68611 | GEO
2013-05-01 | E-GEOD-44619 | biostudies-arrayexpress
2015-04-28 | E-GEOD-46361 | biostudies-arrayexpress
| MSV000082890 | MassIVE
2010-03-22 | E-GEOD-17511 | biostudies-arrayexpress
2008-12-18 | GSE14011 | GEO