Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression in canine uterine bacterial infection

ABSTRACT: The study was undertaken to analyze the effect of canine uterine bacterial infection (Pyometra) on local gene expression patterns in the uteri. The results show profound upregulation of various expected genes related to both the innate and innate immune system. In addition, there was a marked upregulation of many genes associated with proteolysis. Moreover, the bacterial disease resulted in downregulation of a large number of homeobox and zinc finger transcription factors. Keywords: Expression profiling by array Gene expression patterns in the uterus from dogs with pyometra disease compared to healthy dogs. 4 replicates each.

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Gunnar Pejler 

PROVIDER: E-GEOD-17878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors.

Hagman Ragnvi R   Rönnberg Elin E   Pejler Gunnar G  

PloS one 20091126 11

<h4>Background</h4>Bacterial infection with the severe complication of sepsis is a frequent and serious condition, being a major cause of death worldwide. To cope with the plethora of occurring bacterial infections there is therefore an urgent need to identify molecular mechanisms operating during the host response, in order both to identify potential targets for therapeutic intervention and to identify biomarkers for disease. Here we addressed this issue by studying global gene expression in ut  ...[more]

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