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HepaRG cells as a model of the primary human hepatocyte transcriptome

ABSTRACT: The aim of this experiment is to determine the similarities and differences between gene expression profiles in HepaRG cells versus primary human hepatocytes, human liver, and the commonly used HepG2 cell. We compared the gene expression profiles from replicate triplicate biological samples of human liver, primary human hepatocytes, HepG2 cells, and HepaRG at differing levels of maturity (differentiated and undifferentiated).

ORGANISM(S): Homo sapiens

SUBMITTER: Steven Hart 

PROVIDER: E-GEOD-18269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

Hart Steven N SN   Li Ye Y   Nakamoto Kaori K   Subileau Eva-anne EA   Steen David D   Zhong Xiao-bo XB  

Drug metabolism and disposition: the biological fate of chemicals 20100312 6

HepaRG cells, derived from a female hepatocarcinoma patient, are capable of differentiating into biliary epithelial cells and hepatocytes. More importantly, differentiated HepaRG cells are able to maintain activities of many xenobiotic-metabolizing enzymes, and expression of the metabolizing enzyme genes can be induced by xenobiotics. The ability of these cells to express and induce xenobiotic-metabolizing enzymes is in stark contrast to the frequently used HepG2 cells. The previous studies have  ...[more]

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