Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hélène Dubois-Pot-Schneider
PROVIDER: E-GEOD-52989 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Dubois-Pot-Schneider Hélène H Fekir Karim K Coulouarn Cédric C Glaise Denise D Aninat Caroline C Jarnouen Kathleen K Le Guével Rémy R Kubo Takashi T Ishida Seiichi S Morel Fabrice F Corlu Anne A
Hepatology (Baltimore, Md.) 20141029 6
<h4>Unlabelled</h4>Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and resistance to therapies. Recent studies have reported that HCC may be derived not only from adult hepatocytes and hepatoblasts but also hepatic stem/progenitors. In this context, HepaRG cells may represent a suitable cellular model to study stem/progenitor cancer cells and the retrodifferentiation of tumor-derived hepatocyte-like cells. Indeed, they differentiate into hepatocyte- and biliary-like cells. ...[more]