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Importance of histone demethylation in adipogenic differentiation and function

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE18598: Differentiating 3T3-L1 adipocytes, introduced with siRNA against aof2 and rfk genes, or treated with tranylcypromine GSE18599: Differentiating 3T3-L1 adipocytes, introduced with siRNA against phf21a gene Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Mitsuyoshi Nakao

PROVIDER: E-GEOD-18600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.

Hino Shinjiro S Sakamoto Akihisa A Nagaoka Katsuya K Anan Kotaro K Wang Yuqing Y Mimasu Shinya S Umehara Takashi T Yokoyama Shigeyuki S Kosai Ken-Ichiro K Nakao Mitsuyoshi M

Nature communications 20120327

Environmental factors such as nutritional state may act on the epigenome that consequently contributes to the metabolic adaptation of cells and the organisms. The lysine-specific demethylase-1 (LSD1) is a unique nuclear protein that utilizes flavin adenosine dinucleotide (FAD) as a cofactor. Here we show that LSD1 epigenetically regulates energy-expenditure genes in adipocytes depending on the cellular FAD availability. We find that the loss of LSD1 function, either by short interfering RNA or b ...[more]

PMID: 22453831

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