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Transcription profiling of mouse back skin during the hair growth cycle to identify hair cycle-associated genes


ABSTRACT: Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance. Proc. Natl. Acad. Sci. USA. (2004)

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lin 

PROVIDER: E-GEOD-1912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance.

Lin Kevin K KK   Lin Kevin K KK   Chudova Darya D   Hatfield G Wesley GW   Smyth Padhraic P   Andersen Bogi B  

Proceedings of the National Academy of Sciences of the United States of America 20041101 45


The hair-growth cycle is an example of a cyclic process that is well characterized morphologically but understood incompletely at the molecular level. As an initial step in discovering regulators in hair-follicle morphogenesis and cycling, we used DNA microarrays to profile mRNA expression in mouse back skin from eight representative time points. We developed a statistical algorithm to identify the set of genes expressed within skin that are associated specifically with the hair-growth cycle. Th  ...[more]

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