Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms


ABSTRACT: Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthritis patients were compared to those from osteoarthritis patients and to normal donors. Keywords: disease state analysis Two disease conditions (rheumatoid arthritis and osteoarthritis) in comparison to normal donors were investigated. For the two disease groups samples derived from three individual patients and two pools of patients were hybridised.

ORGANISM(S): Homo sapiens

SUBMITTER: Ute Ungethuem 

PROVIDER: E-GEOD-1919 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis.

Ungethuem U U   Haeupl T T   Witt H H   Koczan D D   Krenn V V   Huber H H   von Helversen T M TM   Drungowski M M   Seyfert C C   Zacher J J   Pruss A A   Neidel J J   Lehrach H H   Thiesen H J HJ   Ruiz P P   Bläss S S  

Physiological genomics 20100921 4


Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced interpatient heterogeneity. To characterize RA at the molecular level and to uncover pathomechanisms, we performed genome-wide gene expression analysis. We identified a set of 1,054 genes significantly deregulated in pair-wise comparisons between RA and osteoarthritis (OA) patients, RA and normal donors (ND), or OA and ND. Correlation analysis revealed gene sets regulated identically in all thre  ...[more]

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