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Transcription profiling of human synovial cells isolated from patients with rheumatoid arthritis

ABSTRACT: Rheumatoid arthritis (RA), a chronic and systemic disease of unknown etiology, is characterized by hyperplasia of synovial cells, which ultimately lead to the destruction of cartilage and bone. To elucidate the molecular mechanisms that lead to RA, we analyzed synovial cells established from patient with RA by oligonucleotide microarrays. Gene expression profiles reveal a novel pathophysiologic function of RA synovial cells as a generator of oxidative stress, and a self-defense mechanism against self-generated oxidative stress. Experiment Overall Design: We isolated synovial cell culture from patients with rheumatoid arthritis and osteoarthritis. Fibroblast from patient with osteoarthritis was used for the reference.

ORGANISM(S): Homo sapiens

SUBMITTER: Yoshimi Homma

PROVIDER: E-GEOD-9329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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