Distinct epithelial gene expression phenotypes in childhood respiratory allergy
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kevin Lebrigand
PROVIDER: E-GEOD-19190 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Distinct epithelial gene expression phenotypes in childhood respiratory allergy.
Giovannini-Chami Lisa L Marcet Brice B Moreilhon Chimène C Chevalier Benoît B Illie Marius I MI Lebrigand Kévin K Robbe-Sermesant Karine K Bourrier Thierry T Michiels Jean-François JF Mari Bernard B Crénesse Dominique D Hofman Paul P de Blic Jacques J Castillo Laurent L Albertini Marc M Barbry Pascal P
The European respiratory journal 20111017 5
Epithelial cell contribution to the natural history of childhood allergic respiratory disease remains poorly understood. Our aims were to identify epithelial pathways that are dysregulated in different phenotypes of respiratory allergy. We established gene expression signatures of nasal brushings from children with dust mite-allergic rhinitis, associated or not associated with controlled or uncontrolled asthma. Supervised learning and unsupervised clustering were used to predict the different su ...[more]
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