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S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells [HG-U133B]

ABSTRACT: Pancreatic cancer is a devastating disease with both local invasion and distant metastasis. Identifying the genes expressed in liver metastases and signatures of metastatic progression would therefore be of particular importance as they could aid in both recurrence prediction as well as representing novel therapeutic targets. Keywords: Gene expression profiling We have performed microarray gene expression analysis of normal pancreas, primary pancreatic ductal adenocarcinoma (PDAC), normal liver and pancreatic liver metastases to identify potential therapeutic targets.

ORGANISM(S): Homo sapiens

SUBMITTER: Claude Chelala

PROVIDER: E-GEOD-19280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells.

Barry Sayka S Chelala Claude C Lines Kate K Sunamura Makoto M Wang Amu A Marelli-Berg Federica M FM Brennan Caroline C Lemoine Nicholas R NR Crnogorac-Jurcevic Tatjana T

Clinical & experimental metastasis 20120925 3

Pancreatic ductal adenocarcinoma (PDAC) is the 5th most common cause of cancer death in the UK and the 4th in the US. The vast majority of deaths following pancreatic cancer are due to metastatic spread, hence understanding the metastatic process is vital for identification of critically needed novel therapeutic targets. An enriched set of 33 genes differentially expressed in common between primary PDAC and liver metastases, when compared to normal tissues, was obtained through global gene expre ...[more]

PMID: 23007696

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