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CX43 heterozygous, Cx43 null and Cx32 null vs wildtype neonatal mouse brain

ABSTRACT: Cy3-labeled cDNA from brains of neonatal C57BL Cx43 null, Cx43 heterozygous and Cx32 null mice were compared among themselves and to Cy3-labeled cDNA from brains of neonatal C57BL wildtype mice through Cy5-labeled sample reference prepared at once for the entire experiment from aorta, brain, heart, kidney, liver, lung, ovary/testicles, spleen, and stomach - equal amounts from adult male and female C57BL mice.

ORGANISM(S): Mus musculus

SUBMITTER: Dumitru Iacobas 

PROVIDER: E-GEOD-1954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sensitivity of the brain transcriptome to connexin ablation.

Iacobas Dumitru A DA   Iacobas Sanda S   Urban-Maldonado Marcia M   Spray David C DC  

Biochimica et biophysica acta 20041222 2

Extensive studies on mice with total or partial disruption of either connexin43 (Cx43) or connexin32 (Cx32) have detected only subtle changes in central nervous system structure, growth, development, or function. We have used high density cDNA arrays to analyze the regulation, control, and coordination of the abundances of 7446 distinct transcripts in four brains, each of Cx43 null (K43), Cx43 heterozygous (H43), and Cx32 null (K32) mice as compared to the brains of wildtype (W) mice. The use of  ...[more]

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