Dataset Information
Mouse sciatic nerve profile of CMT1A peripheral neuropathy model, caused by PMP22 overexpression
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anneloor ten Asbroek
PROVIDER: E-GEOD-1962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression profiling of sciatic nerve in a Charcot-Marie-Tooth disease type 1a mouse model.
Journal of neuroscience research 20050301 6
Expression profiling was performed on sciatic nerve of normal mice and of transgenic mice overexpressing the peripheral myelin protein 22 kDa (PMP22). These mice represent a model for the hereditary peripheral neuropathy Charcot-Marie Tooth type 1A. Comparison of the profiles reveals that the proteasomal degradation pathway and various signaling mechanisms are up-regulated in the diseased nerve. The down-regulated processes represent cell shape and adhesion as well as cellular activity and metab ...[more]
