Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mario Lauria
PROVIDER: E-GEOD-19836 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
De Cegli Rossella R Romito Antonio A Iacobacci Simona S Mao Lei L Lauria Mario M Fedele Anthony O AO Klose Joachim J Borel Christelle C Descombes Patrick P Antonarakis Stylianos E SE di Bernardo Diego D Banfi Sandro S Ballabio Andrea A Cobellis Gilda G
Genome biology 20100622 6
<h4>Background</h4>Dosage imbalance is responsible for several genetic diseases, among which Down syndrome is caused by the trisomy of human chromosome 21.<h4>Results</h4>To elucidate the extent to which the dosage imbalance of specific human chromosome 21 genes perturb distinct molecular pathways, we developed the first mouse embryonic stem (ES) cell bank of human chromosome 21 genes. The human chromosome 21-mouse ES cell bank includes, in triplicate clones, 32 human chromosome 21 genes, which ...[more]