Unknown,Transcriptomics,Genomics,Proteomics

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Loss of BTG1 function promotes ETV6-RUNX1-mediated leukemic transformation by upregulation of BCL6


ABSTRACT: Analysis of gene signatures in WT+Ctrl vs WT+ETV6-RUNX1, Btg1-/- and Btg1-/-+ETV6-RUNX1 in cKit+Ter119- fetal liver-derived hematopoietic progenitor cells (FL-HPCs). The Btg1-/-+ETV6-RUNX1 FL-HPCs display a strong increase in proliferation compared to WT+ETV6-RUNX1. Total RNA otained from WT+Ctrl, WT+ETV6-RUNX1, Btg1-/-+Ctrl and Btg1-/-+ETV6-RUNX1 FL-HPCs cells that were cultured for 12 days in expansion medium.

ORGANISM(S): Mus musculus

SUBMITTER: Frank van Leeuwen 

PROVIDER: E-GEOD-60589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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