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Transcription profiling of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21

ABSTRACT: Detection of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21.

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Bliss

PROVIDER: E-MEXP-409 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.

O'Doherty Aideen A Ruf Sandra S Mulligan Claire C Hildreth Victoria V Errington Mick L ML Cooke Sam S Sesay Abdul A Modino Sonie S Vanes Lesley L Hernandez Diana D Linehan Jacqueline M JM Sharpe Paul T PT Brandner Sebastian S Bliss Timothy V P TV Henderson Deborah J DJ Nizetic Dean D Tybulewicz Victor L J VL Fisher Elizabeth M C EM

Science (New York, N.Y.) 20050901 5743

Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated mouse embryonic stem cells and generated a trans-species aneuploid mouse line that stably transmits a freely segregating, almost complete human chromosome 21 (Hsa21). This "transchromosomic" mouse line, Tc1, is a model of trisomy 21, which manifests as Down syndrome (DS) in humans, and has phenotypic ...[more]

PMID: 16179473

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