Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse left ventricle from male (-/-) (n=3) and (+/+) (n=4) at the age of 21M to do exercise and transcriptional analysis in male eNOS Knockout Mice

ABSTRACT: There is cardiac dysfunction in male eNOS (-/-) with age and 50% mortality at 21M. It was of interest to investigate the gene expression profile of aged eNOS (-/-) male in comparison to (+/+) in order to explore the genetic markers and molecular mechanisms leading to heart failure. RNA was extracted from the left ventricle from male (-/-) (n=3) and (+/+) (n=4) at the age of 21M.

ORGANISM(S): Mus musculus

SUBMITTER: Caroline Ojaimi 

PROVIDER: E-GEOD-1988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype.

Ojaimi Caroline C   Li Wei W   Kinugawa Shintaro S   Post Heiner H   Csiszar Anna A   Pacher Pal P   Kaley Gabor G   Hintze Thomas H TH  

American journal of physiology. Heart and circulatory physiology 20050506 4

Endothelium-derived nitric oxide (NO) is pivotal in regulating mitochondrial O(2) consumption (Vo(2)) and glucose uptake in mice. The aim of this study was to investigate the mechanism of age- and genotype-related exercise limitation in male endothelial NO synthase (eNOS)-knockout (KO, n = 16) and wild-type (WT, n = 19) mice. Treadmill testing was performed at 12, 14, 16, 18, and 21 mo of age. Vo(2), CO(2) production, respiratory exchange ratio, and maximal running distance were determined durin  ...[more]

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