Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Richard Beyer
PROVIDER: E-GEOD-20479 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gross-Steinmeyer Kerstin K Stapleton Patricia L PL Tracy Julia H JH Bammler Theo K TK Strom Stephen C SC Eaton David L DL
Toxicological sciences : an official journal of the Society of Toxicology 20100504 2
Primary cultures of human hepatocytes were used to investigate whether the dietary isothiocyanates, sulforaphane (SFN), and phenethyl isothiocyanate (PEITC) can reduce DNA adduct formation of the hepatocarcinogen aflatoxin B(1) (AFB). Following 48 h of pretreatment, 10 and 50 microM SFN greatly decreased AFB-DNA adduct levels, whereas 25muM PEITC decreased AFB-DNA adducts in some but not all hepatocyte preparations. Microarray and quantitative reverse transcriptase (RT)-PCR analyses of gene expr ...[more]