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Adult Caenorhabditis elegans: wild-type (N2) and mir-243 mutant worms

ABSTRACT: Transcriptional profiling of N2 vs. mir-243 worms, aiming to identify direct and indirect targets of the microRNA. N2 and mir-243 young-adult worms grown at 20C were analyzed. Three biological replicates with dye-swaps were performed.

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Rene Ketting 

PROVIDER: E-GEOD-20558 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA-directed siRNA biogenesis in Caenorhabditis elegans.

Corrêa Régis L RL   Steiner Florian A FA   Berezikov Eugene E   Ketting René F RF  

PLoS genetics 20100408 4

RNA interference (RNAi) is a post-transcriptional silencing process, triggered by double-stranded RNA (dsRNA), leading to the destabilization of homologous mRNAs. A distinction has been made between endogenous RNAi-related pathways and the exogenous RNAi pathway, the latter being essential for the experimental use of RNAi. Previous studies have shown that, in Caenorhabditis elegans, a complex containing the enzymes Dicer and the Argonaute RDE-1 process dsRNA. Dicer is responsible for cleaving ds  ...[more]

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