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Genome-wide analysis of fetal adrenocortical cells gene expression after 48 h ACTH treatment

ABSTRACT: Analysis of ACTH-regulation on adrenocortical cells at gene expression level. The hypothesis tested in the present study was that ACTH increases chronic cell growth and steroidogenesis in adrenal glands by changing the gene expression profile. Results provide important information on the changes of gene expression of adrenocortical cells after chronic ACTH treatment. Total RNA obtained from primary cultured fetal adrenal cells subjected to 48 hours in vitro treatment of ACTH compared to untreated control cell.

ORGANISM(S): Homo sapiens

SUBMITTER: William Rainey

PROVIDER: E-GEOD-20675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ACTH is a potent regulator of gene expression in human adrenal cells.

Xing Yewei Y Parker C Richard CR Edwards Michael M Rainey William E WE

Journal of molecular endocrinology 20100511 1

The adrenal glands are the primary source of minerocorticoids, glucocorticoids, and the so-called adrenal androgens. Under physiological conditions, cortisol and adrenal androgen synthesis are controlled primarily by ACTH. Although it has been established that ACTH can stimulate steroidogenesis, the effects of ACTH on overall gene expression in human adrenal cells have not been established. In this study, we defined the effects of chronic ACTH treatment on global gene expression in primary cultu ...[more]

PMID: 20460446

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