Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of adrenocortical cells gene expression after 48 h ACTH treatment


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE20669: Genome-wide analysis of adult adrenocorical cells gene expression after 48 h ACTH treatment GSE20675: Genome-wide analysis of fetal adrenocorical cells gene expression after 48 h ACTH treatment Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: yewei xing 

PROVIDER: E-GEOD-20676 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

ACTH is a potent regulator of gene expression in human adrenal cells.

Xing Yewei Y   Parker C Richard CR   Edwards Michael M   Rainey William E WE  

Journal of molecular endocrinology 20100511 1


The adrenal glands are the primary source of minerocorticoids, glucocorticoids, and the so-called adrenal androgens. Under physiological conditions, cortisol and adrenal androgen synthesis are controlled primarily by ACTH. Although it has been established that ACTH can stimulate steroidogenesis, the effects of ACTH on overall gene expression in human adrenal cells have not been established. In this study, we defined the effects of chronic ACTH treatment on global gene expression in primary cultu  ...[more]

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