Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: John Harty
PROVIDER: E-GEOD-53200 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Starbeck-Miller Gabriel R GR Xue Hai-Hui HH Harty John T JT
The Journal of experimental medicine 20131223 1
TCR ligation and co-stimulation induce cellular division; however, optimal accumulation of effector CD8 T cells requires direct inflammatory signaling by signal 3 cytokines, such as IL-12 or type I IFNs. Although in vitro studies suggest that IL-12/type I IFN may enhance T cell survival or early proliferation, the mechanisms underlying optimal accumulation of CD8 T cells in vivo are unknown. In particular, it is unclear if disparate signal 3 cytokines optimize effector CD8 T cell accumulation by ...[more]