Epigenomic profiling of 3T3-L1 adipogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tarjei Mikkelsen
PROVIDER: E-GEOD-21365 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Comparative epigenomic analysis of murine and human adipogenesis.
Mikkelsen Tarjei S TS Xu Zhao Z Zhang Xiaolan X Wang Li L Gimble Jeffrey M JM Lander Eric S ES Rosen Evan D ED
Cell 20101001 1
We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis. The data provide high-resolution views of chromatin remodeling during cellular differentiation and allow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elements based on dynamic chromatin signatures. We find that the specific locations of most such elements d ...[more]
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