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Epigenomic profiling of hASC adipogenesis

ABSTRACT: hASC pre-adipocyte cells were grown to confluence and induced to differentiate in adipogenic media. Examination of 6 histone modifications and CTCF at 4 time points and PPARG at 1 time point using ChIP-Seq

ORGANISM(S): Homo sapiens

SUBMITTER: Tarjei Mikkelsen

PROVIDER: E-GEOD-21366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative epigenomic analysis of murine and human adipogenesis.

Mikkelsen Tarjei S TS Xu Zhao Z Zhang Xiaolan X Wang Li L Gimble Jeffrey M JM Lander Eric S ES Rosen Evan D ED

Cell 20101001 1

We report the generation and comparative analysis of genome-wide chromatin state maps, PPARγ and CTCF localization maps, and gene expression profiles from murine and human models of adipogenesis. The data provide high-resolution views of chromatin remodeling during cellular differentiation and allow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elements based on dynamic chromatin signatures. We find that the specific locations of most such elements d ...[more]

PMID: 20887899

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