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Expression data from testis of day-7 Sohlh1 knock-out mice

ABSTRACT: Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform. The following mice were analyzed at postnatal day 7: wild-type, Sohlh1-/-, and Sphlh2-/-. 4 samples/group.

ORGANISM(S): Mus musculus

SUBMITTER: Aleksandar Rajkovic

PROVIDER: E-GEOD-21525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sohlh1 is essential for spermatogonial differentiation.

Ballow D D Meistrich M L ML Matzuk M M Rajkovic A A

Developmental biology 20060329 1

Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (bHLH) transcription factor). In males, Sohlh1 is preferentially expressed in prespermatogonia and Type A spermatogonia. Loss of Sohlh1 causes infertility by disrupting spermatogonial ...[more]

PMID: 16564520

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