Resting versus activated T cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: john Iacomini
PROVIDER: E-GEOD-21753 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten.
Jindra Peter T PT Bagley Jessamyn J Godwin Jonathan G JG Iacomini John J
Journal of immunology (Baltimore, Md. : 1950) 20100614 2
T cell activation requires signaling through the TCR and costimulatory molecules, such as CD28. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally and are also known to be involved in lymphocyte development and function. In this paper, we set out to examine potential roles of miRNAs in T cell activation, using genome-wide expression profiling to identify miRNAs differentially regulated following T cell activation. One of the miRNAs upregulated after T ...[more]
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