Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of NIH3T3 cells treated with platelet-derived growth factor and Src kinase inhibitors to identify immediate early genes that are induced by PDGF through Src family kinases and other kinases.


ABSTRACT: This experiment was performed to identify immediate early genes that were induced by PDGF specifically through Src family kinases (SFKs), MEK1/2, or PI 3-K.

ORGANISM(S): Mus musculus

SUBMITTER: Paul Bromann 

PROVIDER: E-GEOD-2196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts.

Bromann Paul A PA   Korkaya Hasan H   Webb Craig P CP   Miller Jeremy J   Calvin Tammy L TL   Courtneidge Sara A SA  

The Journal of biological chemistry 20050105 11


The Src family of protein-tyrosine kinases (SFKs) participates in a variety of signal transduction pathways, including promotion of cell growth, prevention of apoptosis, and regulation of cell interactions and motility. In particular, SFKs are required for the mitogenic response to platelet-derived growth factor (PDGF). However, it is not clear whether there is a discrete SFK-specific pathway leading to enhanced gene expression or whether SFKs act to generally enhance PDGF-stimulated gene expres  ...[more]

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