Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Bromann
PROVIDER: E-GEOD-2196 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bromann Paul A PA Korkaya Hasan H Webb Craig P CP Miller Jeremy J Calvin Tammy L TL Courtneidge Sara A SA
The Journal of biological chemistry 20050105 11
The Src family of protein-tyrosine kinases (SFKs) participates in a variety of signal transduction pathways, including promotion of cell growth, prevention of apoptosis, and regulation of cell interactions and motility. In particular, SFKs are required for the mitogenic response to platelet-derived growth factor (PDGF). However, it is not clear whether there is a discrete SFK-specific pathway leading to enhanced gene expression or whether SFKs act to generally enhance PDGF-stimulated gene expres ...[more]