Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic profiling of peripheral blood mononuclear cells from patients with ParkinsonM-bM-^@M-^Ys disease and control subjects.


ABSTRACT: To get insight into systemic molecular events associated with ParkinsonM-bM-^@M-^Ys disease (PD), an age-related neurodegenerative disorder, we compared gene expression patterns of peripheral blood mononuclear cells (PBMC) derived from elderly healthy controls and from PD patients. Transcriptomic profiling of patients with ParkinsonM-bM-^@M-^Ys disease and control subjects. RNA were extracted from peripheral mononuclear blood cells and were hybridized on 4x44k Agilent expression microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: frM-CM-)dM-CM-)ric leprM-CM-*tre 

PROVIDER: E-GEOD-22491 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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To gain insight into systemic molecular events associated with an age-related neurodegenerative disorder, we compared gene expression patterns in peripheral blood mononuclear cells (PBMCs) sampled from elderly, healthy controls and from Parkinson's disease (PD) patients carrying the most frequently found mutation of the LRRK2 gene (G2019S). A transcriptomic approach enabled us to detect differentially expressed genes and revealed perturbations of pathways known to be involved in PD-related neuro  ...[more]

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