Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: frM-CM-)dM-CM-)ric leprM-CM-*tre
PROVIDER: E-GEOD-22491 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mutez Eugénie E Larvor Lydie L Leprêtre Frédéric F Mouroux Vincent V Hamalek Dorota D Kerckaert Jean-Pierre JP Pérez-Tur Jordi J Waucquier Nawal N Vanbesien-Mailliot Christel C Duflot Aurélie A Devos David D Defebvre Luc L Kreisler Alexandre A Frigard Bernard B Destée Alain A Chartier-Harlin Marie-Christine MC
Neurobiology of aging 20100122 10
To gain insight into systemic molecular events associated with an age-related neurodegenerative disorder, we compared gene expression patterns in peripheral blood mononuclear cells (PBMCs) sampled from elderly, healthy controls and from Parkinson's disease (PD) patients carrying the most frequently found mutation of the LRRK2 gene (G2019S). A transcriptomic approach enabled us to detect differentially expressed genes and revealed perturbations of pathways known to be involved in PD-related neuro ...[more]