Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse leukocytes from blood and spleen obtained from animals treated with trauma-hemorrhage, burn injury or lipopolysaccharide (LPS)-infusion


ABSTRACT: gene expression profiles of leukocytes from blood (WBCs) and spleen harvested at an early (two hours) time point after injury or sham injury in mice subjected to trauma-hemorrhage, burn injury or lipopolysaccharide (LPS)-infusion at three experimental sites

ORGANISM(S): Mus musculus

SUBMITTER: IDDC Inflammation the Host Response to Injury 

PROVIDER: E-GEOD-2278 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Commonality and differences in leukocyte gene expression patterns among three models of inflammation and injury.

Brownstein Bernard H BH   Logvinenko Tanya T   Lederer James A JA   Cobb J Perren JP   Hubbard William J WJ   Chaudry Irshad H IH   Remick Daniel G DG   Baker Henry V HV   Xiao Wenzhong W   Mannick John A JA  

Physiological genomics 20051220 3


The aim of this study was to compare gene expression profiles of leukocytes from blood (white blood cells; WBCs) and spleen harvested at an early time point after injury or sham injury in mice subjected to trauma/hemorrhage, burn injury, or lipopolysaccharide (LPS) infusion at three experimental sites. Groups of injured or LPS-infused animals and sham controls were killed at 2 h after injury and resuscitation, blood and spleen were harvested, and leukocyte populations were recovered after erythr  ...[more]

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