MRNA Expression Profiling of pooled medulloblastoma samples
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stefan Pfister
PROVIDER: E-GEOD-22823 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.
Milde Till T Oehme Ina I Korshunov Andrey A Kopp-Schneider Annette A Remke Marc M Northcott Paul P Deubzer Hedwig E HE Lodrini Marco M Taylor Michael D MD von Deimling Andreas A Pfister Stefan S Witt Olaf O
Clinical cancer research : an official journal of the American Association for Cancer Research 20100422 12
<h4>Purpose</h4>Medulloblastomas are the most common malignant brain tumors in childhood. Survivors suffer from high morbidity because of therapy-related side effects. Thus, therapies targeting tumors in a specific manner with small molecules such as histone deacetylase (HDAC) inhibitors are urgently warranted. This study investigated the expression levels of individual human HDAC family members in primary medulloblastoma samples, their potential as risk stratification markers, and their roles i ...[more]
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