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Fgf8 E18.5 hypomorph versus control mouse fetal lungs

ABSTRACT: We set out to look for genome wide gene expression changes due to deficiency of Fgf8 in the lung. RNA from 3 lungs from each genotype (mutant and littermate wild type control) are pooled for each cDNA synthesis and hybridized to individual array for a quadruple biologic repeat of the experiment

ORGANISM(S): Mus musculus

SUBMITTER: Anne Moon

PROVIDER: E-GEOD-22893 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.

Yu Shibin S Poe Bryan B Schwarz Margaret M Elliot Sarah A SA Albertine Kurt H KH Fenton Stephen S Garg Vidu V Moon Anne M AM

Developmental biology 20100819 1

The fibroblast growth factor, FGF8, has been shown to be essential for vertebrate cardiovascular, craniofacial, brain and limb development. Here we report that Fgf8 function is required for normal progression through the late fetal stages of lung development that culminate in alveolar formation. Budding, lobation and branching morphogenesis are unaffected in early stage Fgf8 hypomorphic and conditional mutant lungs. Excess proliferation during fetal development disrupts distal airspace formation ...[more]

PMID: 20727874

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