Unknown,Transcriptomics,Genomics,Proteomics

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Comprehensive profiling of the early lung immune responses in the mouse model of tuberculosis


ABSTRACT: The lung host immune responses following M.tuberculosis infection in the mouse model of tuberculosis were assayed by studying the gene expression profiles at day 0, day 12, 15 and 21 post infection Mice were infected with M.tuberculosis via the aerosol route and the host gene induction during early immune response studied

ORGANISM(S): Mus musculus

SUBMITTER: Dongwan Kang 

PROVIDER: E-GEOD-23014 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Profiling early lung immune responses in the mouse model of tuberculosis.

Kang Dongwan D DD   Lin Yinyao Y   Moreno Javier-Rangel JR   Randall Troy D TD   Khader Shabaana A SA  

PloS one 20110113 1


Tuberculosis (TB) is caused by the intracellular bacteria Mycobacterium tuberculosis, and kills more than 1.5 million people every year worldwide. Immunity to TB is associated with the accumulation of IFNγ-producing T helper cell type 1 (Th1) in the lungs, activation of M.tuberculosis-infected macrophages and control of bacterial growth. However, very little is known regarding the early immune responses that mediate accumulation of activated Th1 cells in the M.tuberculosis-infected lungs. To def  ...[more]

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